The results of a meta-analysis presented at DDW 2013, held in May 2013 in Orlando, suggest that hepatitis B virus (HBV) infection is a risk factor for non-hodgkin lymphoma (NHL).
Investigators at the Marshfield Clinic, Marshfield, Wisconsin, and the University of Mississippi at Jackson, evaluated 19 studies (13,947 cases, 1,559,448 controls) from Europe, South Korea, Japan, Taiwan, Singapore, China, Pakistan, Egypt, and Saudi Arabia. Hepatitis B was diagnosed by detection of HBsAg (17 studies) and by self-report history (two studies). Non-hodgkin lymphoma was diagnosed by histopathology. Controls were non-lymphoma cancer/hospital patients (nine studies), healthy population (eight studies), and both (two studies). According to the researchers, 1205 cases of HBV infection were found in the NHL cases group; 40,592 HBV infection were present in the control group.
Following data analysis, hepatitis B virus infection was higher in patients with NHL compared with the controls (odds ratio 2.53; 95% confidence interval, 2.10 to 3.03, P
<0.001). Additionally, subgroup analysis showed a higher risk of HBV infection in NHL in both developing countries (Asia) and developed countries (Europe). No difference was noted between hospital-based controls and population-based controls.