International Classification of Retinoblastoma can predict high-risk retinoblastoma

   Researchers at the Wills Eye Institute of Thomas Jefferson University, Philadelphia, demonstrated that the International Classification of Retinoblastoma (ICRB) can predict high-risk retinoblastoma (RB).

   To determine the correlation of ICRB and histopathologic high-risk RB, they performed a retrospective study of 519 primarily enucleated eyes (17% group D, 83% group E based on ICRB). According to the researchers, high-risk RB was identified in 23% of enucleated eyes, including 17% of group D and 24% of group E. On logistic regression analysis, massive posterior uveal invasion >3 mm was more common in group D eyes (P=0.0442), and postlaminar optic nerve invasion was more common in group E eyes (P=0.0390).