Joao B. Malta, MD, of the W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, and colleagues evaluated the safety and efficacy of corneal crosslinking (CXL) and refractive surface ablation (PRK) for refractive correction in patients with bilateral asymmetric topography.
They conducted a prospective, randomized trial of 44 patients (88 eyes). The researchers performed CXL with subsequent PRK after six months in one eye (study group), and PRK alone in contralateral eyes (control group). After 1.5 years of follow-up, a mean undercorrection of -0.50 DE was observed in both groups. The study group presented more corneal haze (P
<0.05), and none of the patients developed cornea ectasia.
Dr. Malta and colleagues concluded that both groups achieved good outcomes with a low rate of complications.