Researchers from Johns Hopkins University in Baltimore compared retinal sensitivity after intravitreal aflibercept injection (IAI) and laser photocoagulation.
Retinal sensitivity was assessed by microperimetry in a subset of 43 patients randomized to laser or IAI, 0.5-mg or 2-mg regimens. Following data analysis, the mean change from baseline in visual acuity in the pooled IAI groups vs laser was 11.5 vs -1.3 letters (P
<0.0001) at week 52 in the total cohort. In the microperimetry study, mean changes in retinal sensitivity from baseline were IAI, 2.0 dB (P < 0.001) and laser, -0.8 dB (P
The researchers concluded that IAI-treated patients had improved retinal sensitivity in an exploratory study of diabetic macular edema patients.