Frequent persistent nausea is common in migraine (45.2%) and associated with female gender, age, depression, and headache impact, according to a study by Richard B. Lipton, MD, of the Albert Einstein College of Medicine, Bronx, N.Y., and colleagues.
Of subjects recruited from the American Migraine Prevalence and Prevention Study (N=3526), 8% remained nausea free (occurring never or rarely), 11.9% reported infrequent nausea (/= half the time) in two years. According to the researchers, PFN was more common in younger, female, Caucasian respondents. In adjusted models, depression (odds ratio [OR] 1.89; confidence interval [CI], 1.25 to 2.84) and headache impact (OR 1.87; CI, 1.46 to 2.39) were significant predictors of PFN. Progression to chronic migraine was more common in those with PFN compared with the nausea-free group (4.9% vs 2.7%). In comparison with 2008 data, in 2009 6.5% of migraineurs reported new-onset nausea, 8.8% reported worsening, 11.1% improvement, and 8.5% reported remission of nausea symptoms. “Nausea is an important target in a sizable subgroup of people with migraine,” the researchers concluded.